Reviews in Pharmacy and Pharmaceutical Sciences
Formulation and Biological Implication of Eucalyptus Globulus and Trachspermum ammi Organogel for Topical Delivery
Abstract
Gaurav Singh, Mohd. Washid Khan*, Arun Patel and Chandan Singh Ahirwar
Topical delivery is an interesting option because it is convenient and safe. This offers several potential advantages over conventional routes like avoidance of first-pass metabolism, predictable, minimizing undesirable side effects and most importantly, it provides patient compliance as the drug delivery is painless. Eucalyptol is a hydrophobic, anti-inflammatory drug with a shorter biological half-life. In this context, the jellified emulsion was formulated using Na CMC as a polymer, liquid paraffin as oil phase, emulsifying agents like span 80 and tween 80, oleic acid, and clove oil as permeation enhancers. Studies were carried out with the aim to develop organogel with the different gelling agents for topical application and evaluation of these formulations.