Journal of Medical Sciences and Health Care Research
Neurogenesis and Neuroplasticity in Brain Injury Recovery: Mechanisms and Therapeutic Implications
Abstract
Naeem Hamza, Lin Li Chen, Naeema Zainaba and Nuaman Ahmed
Recovery from brain injury is a dynamic process driven by the synergistic mechanisms of neurogenesis and neuroplasticity. Neurogenesis, the generation of new neurons from neural stem cells, plays a very key role in restoring damaged neural circuits, especially within the hippocampus. Simultaneously, neuroplasticity allows for the reorganization of synaptic connections in the brain and the redistribution of functional tasks to intact parts of the brain, allowing for adaptive recovery. The review comprehensively analyzes these two processes, their interaction, and the therapeutic implications in the recovery after brain injury. Key mechanisms of neurogenesis are discussed in view of experimental findings and difficulties of translation to human clinical contexts. Neuroplasticity is approached according to synaptic plasticity and cortical reorganization, emphasizing its contribution to both short-term and long-term functional recovery.
The interaction of neurogenesis with neuroplasticityis discussed, focusing on how these processes restore brain functions complementarily. Therapeutic approaches, including pharmacological interventions such as growth factors and neuroprotective drugs, and non-pharmacological therapies like cognitive rehabilitation and brain stimulation, are reviewed. Emerging strategies include gene editing and stem cell therapy, along with ethical and translational challenges. This review highlights several critical gaps in the literature at present and seeks to drive future research through translational human clinical trials to bridge basic experimental findings toward clinical applications. This review sets the stage for future priorities in developing brain injury therapies. 25 January, 2025 20, March, 2025 27 March, 2025 Date of Submission: Date of Acceptance: Date of Publication: Volume 1, Issue 1 Research Article Citation: Hamza, N. (2025). Neurogenesis and Neuroplasticity in Brain Injury Recovery: Mechanisms and Therapeutic Implications. J Med Sci Health Care Res, 1(1), 01-07. *Corresponding Author: Naeem Hamza, Student Iuliu Hatieaganu University of Medicine and Pharmacy Cluj Napoca, Romania. Keywords: Neurogenesis, Neuroplasticity, Brain Injury Recovery, Neural Stem Cells, Hippocampus, Synaptic Plasticity, Cortical Reorganization, Growth Factors, Neuroprotective Drugs, Cognitive Rehabilitation, Brain Stimulation, Gene Editing, Stem Cell Therapy, Translational Challenges and Therapeutic Innovation