"The clinical advantage of PEG-IFNa-2B results from the fact that it is very slowly cleared after administration, resulting in a longer terminal elimination half-life (t 1/2 ) and a higher systemic exposure (both AUC and C max ) in both preclinical and clinical studies conferring an increased efficacy compared to IFNa-2B. The pegylation of IFNa- 2B also renders the molecule less immunogenic; Pegasys ® (pegylated Interferon a) is less immunogenic than Roferon ® (native Interferon a). The toxicokinetic profile of PEG-IFNa-2B obtained in a GLP preclinical toxicology study involving the repeated administration of the biopharmaceutical for 13 weeks by the subcutaneous route in Macaca fascicularis.
Last Updated on: Dec 22, 2024List of Open Access Journals View More
Department of Electrical Engineering: Current Research
DEECR welcomes authors to contribute current research and reports, Experimental studies, Review articles, Short communication, Editorial, Letter to Editor, Survey Reports submission of manuscripts related to Signal Processing, Material Science, Microelectronics, Electronic materials, Power System Protection, DC Power Converter, C Power Converter, Electrophysics and its applications, Electromagnetism, etc....View More
Journal of Next Generation Materials Engineering Research
JNGMER welcome authors to contribute current research and reports manuscripts related to Thermal Engineering, Environmental Catalysis, Reaction kinetics, Physical Chemistry, Catalysis & Adsorption, Processes of Heat, Momentum Transfer, Nanocatalysis, Reactor Engineering, Reactor Designs and Materials, and Thermodynamic Engineering, etc...View More
International Journal of Catalysis and Chemical Engineering
International Journal of Catalysis and Chemical Engineering (IJCCE) is a scholarly open access per-reviewed journal aim to publish be valuable source of information in field of Chemical Engineering, Catalysis, Catalytic Materials & Mechanisms, Nanocatalysis....View More
Journal of Environmental and Pollution
JEP is a scholarly open access peer-reviewed journal aim to publish be valuable source of information both experimental and theoretical in the field of environmental issues and Pollution and its applications...View More
Dermatology Case Reports: Open Access Journal
DCROAJ welcome authors to contribute current research and reports, clinical studies, review articles, short communication, editorial, letter to editor, survey reports submission of manuscripts related to devices in dermatology, dermatology studies, new technology in dermatology, biological materials, venereology, leprology etc....View More