"The clinical advantage of PEG-IFNa-2B results from the fact that it is very slowly cleared after administration, resulting in a longer terminal elimination half-life (t 1/2 ) and a higher systemic exposure (both AUC and C max ) in both preclinical and clinical studies conferring an increased efficacy compared to IFNa-2B. The pegylation of IFNa- 2B also renders the molecule less immunogenic; Pegasys ® (pegylated Interferon a) is less immunogenic than Roferon ® (native Interferon a). The toxicokinetic profile of PEG-IFNa-2B obtained in a GLP preclinical toxicology study involving the repeated administration of the biopharmaceutical for 13 weeks by the subcutaneous route in Macaca fascicularis.
Last Updated on: Jan 22, 2025List of Open Access Journals View More
Department of Electrical Engineering: Current Research
DEECR welcomes authors to contribute current research and reports, Experimental studies, Review articles, Short communication, Editorial, Letter to Editor, Survey Reports submission of manuscripts related to Signal Processing, Material Science, Microelectronics, Electronic materials, Power System Protection, DC Power Converter, C Power Converter, Electrophysics and its applications, Electromagnetism, etc....View More
Academic Journal of Chemical Engineering
AJCE is a scholarly open access peer-reviewed journal aim to publish be valuable source of information in field of Chemical science, biophysics, engineering, environmental science, medicine, physical science current research in the field....View More
Review of Cell Science Journal
RCSJ welcome researchers, pharma companies, professors, scientists, biologists, biotechnologists, immunologists, stem cell researchers, clinical scientists, molecular biologists to contribute current research work to the scientific world....View More
Dermatology Case Reports: Open Access Journal
DCROAJ welcome authors to contribute current research and reports, clinical studies, review articles, short communication, editorial, letter to editor, survey reports submission of manuscripts related to devices in dermatology, dermatology studies, new technology in dermatology, biological materials, venereology, leprology etc....View More
Reviews in Pharmacy and Pharmaceutical Sciences
Reviews in Pharmacy and Pharmaceutical sciences is a peer-reviewed scholarly journal that aims to publish high quality research on Pharmacology and Toxicology, Pharmaceutical Chemistry, Pharmaceutical Analysis and Quality Assurance, Pharmaceutics, Hospital and Clinical Pharmacy...View More
Journal of Oncology and Cancer Research
Journal of Oncology and Cancer Research provides a unique platform for all the academicians and professionals to share their knowledge, laboratory findings, discussions which in-turn accelerates the further research in the field of cancer. JOCR manuscripts undergo rigorous...View More