Genotoxic chemicals exert their adverse effect through interaction with genetic material (DNA) of cells. Genotoxicity tests are designed to detect drugs which can induce genetic damage directly or indirectly by various mechanisms of action. Compounds identified as genotoxic in these tests have the potential to be human carcinogens and/or mutagens, and ultimately may induce cancer and/or heritable defects.
Genotoxicity testing of new chemical entities is an integral part of the drug development process and is a regulatory requirement prior to the approval of new drugs. By identifying genotoxicity at an early stage in drug discovery rather than during regulatory assessment, the likelihood of late stage failures is reduced.
Last Updated on: Nov 21, 2024List of Open Access Journals View More
Department of Applied Food and Nutrition Journal
DAFNJ is a scholarly open access peer-reviewed journal aim to publish be valuable source of information both clinical, experimental and theoretical in field of Food science, Food policy and Nutrition....View More
International Journal of Biomedical Science and Research
International Journal of Biomedical Science and Research is an Open Access, peer-reviewed, academic journal that provides an area to share the information by medical scientists and researchers on the topics of biomedical science. Biomedical Science is the field of study that focuses on the areas of biology...View More
International Journal of Catalysis and Chemical Engineering
International Journal of Catalysis and Chemical Engineering (IJCCE) is a scholarly open access per-reviewed journal aim to publish be valuable source of information in field of Chemical Engineering, Catalysis, Catalytic Materials & Mechanisms, Nanocatalysis....View More
Review of Cell Science Journal
RCSJ welcome researchers, pharma companies, professors, scientists, biologists, biotechnologists, immunologists, stem cell researchers, clinical scientists, molecular biologists to contribute current research work to the scientific world....View More
Academic Journal of Chemical Engineering
AJCE is a scholarly open access peer-reviewed journal aim to publish be valuable source of information in field of Chemical science, biophysics, engineering, environmental science, medicine, physical science current research in the field....View More
Journal of Cardiology Research and Endovascular Therapy
The journal focus includes cardiac diseases, cardiovascular surgeries, pathophysiology, screening and epidemiology, vascular diseases, embolic protection, imaging technologies and electrophysiology, drug-eluting stents etc. JCRET articles will be strictly peer-reviewed through double blind...View More