A local anesthetic is a medication that causes the absence of pain sensation. When it is used on specific nerve pathways, paralysis also can be achieved. Clinical LAs belong to one of two classes: aminoamide and aminoester local anesthetics. Synthetic LAs are structurally related to cocaine. LAs act by reversibly blocking the sodium channels of nerve fibers, thereby inhibiting the conduction of nerve impulses. All local anesthetics, with the exception of cocaine, are vasodilators. Vasodilation occurs via direct relaxation of peripheral arteriolar smooth muscle fibers. Greatervasodilator activity of a local anesthetic leads to faster absorption and, thus, shorter duration of action.
Last Updated on: Nov 23, 2024List of Open Access Journals View More
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Journal primary objective is to provide research and applications related to Medical & Health Sciences. This journal strives to serve a diverse readership by publishing articles in a wide range of topics. This journal will welcome articles from the field of all specialities medical science that includes feilds like medicine...View More
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Department of Electrical Engineering: Current Research
DEECR welcomes authors to contribute current research and reports, Experimental studies, Review articles, Short communication, Editorial, Letter to Editor, Survey Reports submission of manuscripts related to Signal Processing, Material Science, Microelectronics, Electronic materials, Power System Protection, DC Power Converter, C Power Converter, Electrophysics and its applications, Electromagnetism, etc....View More