Pharmacokinetics is the study of drug absorption, distribution, metabolism, and excretion. A fundamental concept in pharmacokinetics is drug clearance, that is, elimination of drugs from the body, analogous to the concept of creatinine clearance. AUC, the area under the curve, represents the total drug exposure integrated over time and is an important parameter for both pharmacokinetic and pharmacodynamic analyses. As indicated in the clearance is simply the ratio of the dose to the AUC, so that the higher the AUC for a given dose, the lower the clearance. If a drug is administered by continuous infusion and a steady state is achieved, the clearance can be estimated from a single measurement of the plasma drug concentration (Css). Clearance can conceptually be considered to be a function of both distribution and elimination. In the simplest pharmacokinetic model.
Last Updated on: Jan 22, 2025List of Open Access Journals View More
Journal of Medical Sciences and Health Care Research
Journal primary objective is to provide research and applications related to Medical & Health Sciences. This journal strives to serve a diverse readership by publishing articles in a wide range of topics. This journal will welcome articles from the field of all specialities medical science that includes feilds like medicine...View More
Nanomedicine and Nanoscience Technology: Open Access
Nanomedicine and Nanoscience Technology: Open Access is an Open Access journal and aims to publish most complete and reliable source of information on the applications, discoveries and current developments on nanomedicine and nanoscience technology in the mode of original articles...View More
Clinical Trials and Medical Case Reports
Clinical trials and Medical Case reports is an open access peer reviewed journal. It publishes Clinical trials, Medical case reports and Medical images from all fields of medicine in all orders by which medicinal services experts, specialists and others can easily understand the disease conditions...View More
Endocrinology and Endocrine System
Endocrinology and Endocrine System is an Open Access journal which aims to develop knowledge and to share the information freely by making them available through online without any restrictions or any other subscriptions to researchers worldwide and also to the readers globally...View More
Academic Journal of Chemical Engineering
AJCE is a scholarly open access peer-reviewed journal aim to publish be valuable source of information in field of Chemical science, biophysics, engineering, environmental science, medicine, physical science current research in the field....View More
International Journal of Biomedical Science and Research
International Journal of Biomedical Science and Research is an Open Access, peer-reviewed, academic journal that provides an area to share the information by medical scientists and researchers on the topics of biomedical science. Biomedical Science is the field of study that focuses on the areas of biology...View More